Tetrapyrroles and derivatives
Abcam Necrostatin-1, necroptosis inhibitor, 10MG
MW 259.33 Da, Purity >99%. Potent, specific necroptosis inhibitor (EC₅₀ = 490 nM). Selective allosteric inhibitor of death domain receptor-associated adaptor kinase RIP1 in vitro (EC₅₀ = 182 nM). Caspase independent, programmed necrosis pathway.
The product is subject to the following: Abcam Restricted Use Statement
Abcam L-745870 trihydrochloride, brain penetrant D4 antagonist, 10MG
MW 436.21 g/mol, Purity >99%. Highly potent and selective D₄ antagonist (Ki values are 0.43, 2300 and 960 nM at D₄, D₃ and D₂, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dorsomorphin (Compound C), AMP-kinase inhibitor, 5MG
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
The product is subject to the following: Abcam Restricted Use Statement
Strem, An Ascensus Company CAS# 14609-54-2. 1g. meso-Tetra(4-carboxyphenyl)porphine, 98%. MFCD00064860
CAS# 14609-54-2. 1g. meso-Tetra(4-carboxyphenyl)porphine, 98%. MFCD00064860. Molecular Weight: 790.79. Molecular Formula: C48H30N4O8. Color/form: purple pwdr. Strem# 07-1970. http://www.strem.com/catalog/v/07-1970/
Research Products International Corp Cyanocobalamin (Vitamin B12), 100 Milligrams
Common vitamin of the Vitamin B12 family.
Apexbio Technology LLC Vitamin B12 68-19-9 10mM (in 1mL DMSO)
Vitamin B12 (CAS 68-19-9) is a cobalt-containing water-soluble vitamin involved in hematopoiesis and neuronal function It acts primarily as a cofactor facilitating methyl-transfer reactions notably as methylcobalamin in the synthesis pathway of methionine consequently regulating methylation of DNA RNA and proteins Additionally Vitamin B12 modulates cellular redox homeostasis offering protective effects against oxidative cellular damage Current research engages Vitamin B12 in studies on neurodegenerative disease models immunological inflammation pathways and cellular injury mechanisms related to oxidative stress
TARGETMOL CHEMICALS INC Tin-protoporphyrin IX dichlori
Also available in 1 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Tin-protoporphyrin IX dichloride (SnPPIX dichloride) is an HO-1) inhibitor with antiviral activity that inhibits dengue and yellow fever viruses. Purity 98%
Medchemexpress LLC HY-101193 10mg Medchemexpress, Zinc Protoporphyrin CAS:15442-64-5 Purity:>98%
Medchemexpress, HY-101193 10mg Zinc Protoporphyrin CAS:15442-64-5 Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is a normal metabolite formed in trace amounts during heme biosynthesis and used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Tin protoporphyrin IX dichloride | 14325-05-4 | 96.2% | 750.26 g/mol | C34H32Cl2N4O4Sn | 100 MG
Tin protoporphyrin IX dichloride is a metalloporphyrin research reagent that acts as a potent inhibitor of heme oxygenase enzymes. It is provided as a milligram-scale crystalline solid intended for biochemical and cell-based studies to probe heme metabolism, oxidative stress, and related pathways.
- Potent inhibitor of heme oxygenase enzymes.
- Suitable for in vitro and in vivo research applications.
- Available in milligram-scale sizes, including 100 MG.
- High reported purity for research use (approximately 96.2%).
- Supplied as a stable solid for routine laboratory handling.
Abcam Dihydrokainic acid, EAAT2 (GLT-1) inhibitor, 1MG
MW 215.25 Da. Selective, non-transportable inhibitor of glutamate transporter EAAT2 (GLT-1) (Ki = 23 μM). 130-fold selective over EAAT1 and EAAT3 (Ki > 3 mM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Endothelin-1 (human, porcine), Vasoconstrictor peptide, 500UG
MW 2491.9 Da. Endothelin-1 (human, porcine), Vasoconstrictor peptide. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Nocodazole, Microtubule inhibitor, 50MG
MW 301.32 Da, Purity >98%. Microtubule inhibitor. Rapidly depolymerises microtubules in vivo and inhibits tubulin polymerisation in vitro. Inhibits mitosis. Also reduces stem cell pluripotency factors Oct 4 and Nanog.
The product is subject to the following: Abcam Restricted Use Statement
Abcam WAY-100635 maleate, 5-HT1A receptor antagonist, 10MG
MW 538.6 Da, Purity >98%. Potent, selective, silent 5-HT1A receptor antagonist (IC50 = 1.35 nM). Displays >100-fold selectivity for 5-HT1Arelative to a range of other CNS receptors including other 5-HT subtypes, adrenoceptors, dopamine, GABA, histamine and ion channels. Binds selectively to rodent brain 5-HT1A receptors *in vivo* (iv admin). Unlike WAY100135, WAY100635 displays no partial agonist activity in the ventral hippocampus of rats.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 242084 hydrochloride, 5-HT2C antagonist, 50MG
MW 431.3 Da, Purity >98%. Potent, selective 5-HT2C antagonist (pKi values are 9 (5-HT2C), 7 (5-HT2B), 6.8 (5-HT2A), 6.4 (5-HT1A), 6.4 (5-HT1B), 6.4 (5-HT1D), 6 (5-HT1E), <6.1 (5-HT1F), <5.5 (5-HT4), 6 (5-HT6), 6.1 (5-HT7), 6.2 (D2), 6.2 (D3) and <5 (α1)). Blood-brain barrier permeable. Anxiolytic activity *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement